Mechanochemical fluorination of unactivated tertiary alkyl chlorides
- 31 January 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 27 (8) , 2197-2202
Abstract
We present the first catalyst-free fluorination of unactivated tertiary alkyl halides via ball milling. This method offers short reaction times, minimal solvent usage, and is applicable to the synthesis of key intermediates for ledipasvir.Keywords
Funding Information
- Xi’an Jiaotong University
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