Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
Authors:
Open Access
Abstract
Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).Keywords
This publication has 37 references indexed in Scilit:
- A germline E-cadherin mutation in a family with gastric and colon cancerInternational Journal of Molecular Medicine, 2001
- Prophylactic total gastrectomy for familial gastric cancerSurgery, 2001
- Germline E-cadherin gene mutationsCancer, 2001
- Early Gastric Cancer in Young, Asymptomatic Carriers of Germ-Line E-Cadherin MutationsNew England Journal of Medicine, 2001
- The recognition and endoscopic treatment of early gastric and colonic cancerBest Practice & Research Clinical Gastroenterology, 2001
- Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancerNature Genetics, 2000
- Familial gastric cancer: overview and guidelines for management*: Table 1Journal of Medical Genetics, 1999
- E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancerHuman Mutation, 1999
- E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas.1999
- Germline E-cadherin Gene (CDH1) Mutations Predispose to Familial Gastric Cancer and Colorectal CancerHuman Molecular Genetics, 1999