3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors

This publication has 10 references indexed in Scilit:

• Synthesis of 5‐ethyl‐2‐{5‐[4‐(2‐hydroxyethyl)piperazin‐1‐ylsulfonyl]‐2‐n‐propoxyphenyl}‐7‐n‐propyl‐3,5‐dihydro‐4H‐pyrrolo[3,2‐d]‐[2‐¹⁴C]pyrimidin‐4‐one·2 HCl (¹⁴C‐SK3530·2 HCl)
  Journal of Labelled Compounds and Radiopharmaceuticals, 2006
• Phosphodiesterase 5 (PDE 5) inhibitors for the treatment of male erectile disorder: Attaining selectivity versus PDE6
  Medicinal Research Reviews, 2005
• Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5 ′ -sulfonamide moiety of phenyl ring
  Bioorganic & Medicinal Chemistry Letters, 2004
• Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
  Journal of Biological Chemistry, 2004
• Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
  Nature, 2003
• Phosphodiesterase 5 inhibitors: current status and potential applications
  Nature Reviews Drug Discovery, 2002
• Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5′-sulfonamide moiety of a phenyl ring
  Bioorganic & Medicinal Chemistry, 2001
• Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
  Bioorganic & Medicinal Chemistry, 2001
• Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues
  Bioorganic & Medicinal Chemistry, 2001
• Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
  Bioorganic & Medicinal Chemistry Letters, 1996