Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming
Authors:
- 1 June 2021
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 320 (6) , H2222-H2239
Abstract
Periostin caused arterial calcification, overactivated glycolysis, and damaged OXPHOS. PPARγ agonists alleviated periostin-promoted arterial calcification and corrected abnormal glycolysis and unbalanced mitochondrial homeostasis. There exists a relationship between periostin and lactate in patients with CAC.Keywords
Funding Information
- National Natural Science Foundation of China (81970381)
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