Spontaneous Alteration of Idiotype in a Monoclonal B-Cell Lymphoma
Authors:
- Mark RaffeldMRMark Raffeld
- Leonard NeckersLNLeonard Neckers
- Dan L. LongoDLDan L. Longo
- Jeffrey CossmanJCJeffrey Cossman
- 27 June 1985
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 312 (26) , 1653-1658
Abstract
The surface immunoglobulin of B-cell neoplasms provides a specific point of attack for potential antibody therapy. The capacity of anti-idiotype antibody to home to the target neoplasm requires that the idiotype be unique and that it be expressed by every cell in the neoplastic clone.Keywords
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