P2x7 Receptor and Extracellular Vesicle Release
Preprint
- 2 May 2023
- preprint
- Published by MDPI AG in Preprints.org
Abstract
Extensive evidence indicates that activation of P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.Keywords
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This publication has 83 references indexed in Scilit:
- The systemic disruption of P2rx7 alleviates tau pathology in P301S tau mice via inhibition of extracellular vesicle releaseAlzheimer's & Dementia, 2022
- Astrocytes‐derived extracellular vesicles in motion at the neuron surface: Involvement of the prion proteinJournal of Extracellular Vesicles, 2021
- P2X7 receptor-mediated phenotype switching of pulmonary artery smooth muscle cells in hypoxiaMolecular Biology Reports, 2021
- Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancerSeminars in Immunopathology, 2018
- Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in ratsPurinergic Signalling, 2017
- IL‐18 associates to microvesicles shed from human macrophages by a LPS/TLR‐4 independent mechanism in response to P2X receptor stimulationEuropean Journal of Immunology, 2012
- Myeloid microvesicles are a marker and therapeutic target for neuroinflammationAnnals of Neurology, 2012
- P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathwaysPurinergic Signalling, 2009
- High glucose modulates P2X 7 receptor-mediated function in human primary fibroblastsDiabetologia, 2000
- Secretion of Mammalian Proteins that Lack a Signal Sequence1997