pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood
Open Access
- 14 March 2013
- journal article
- Published by Springer Nature in Journal of Translational Medicine
- Vol. 11 (1) , 65
Abstract
IL-21 has been shown to play an important role in autoimmune diseases. ATR-107 is an antibody which directly targets the IL-21 receptor (IL-21R). To aid the clinical development of ATR-107, there is a need for understanding the mechanism of action (MOA) of this antibody when assessing target engagement in human subjects.Keywords
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