Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II
Open Access
- 15 May 2012
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 590 (10) , 2333-2351
Abstract
Key points Rapid exchange of metabolites like glucose and lactate between different cell types is crucial for energy supply to the brain. Carbonic anhydrase 2 (CAII) enhances lactate transport in mouse cerebellar and cerebral astrocytes. Enhancement of transport activity is independent of the enzyme's catalytic function, but requires binding of CAII to the C‐terminal tail of the monocarboxylate transporter MCT1. CAII could enhance lactate flux by acting as a ‘proton collecting antenna’ for MCT1. By this mechanism CAII could enhance transfer of lactate between astrocytes and neurons and thus provide neurons with an increased supply of energy substrate.Keywords
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