HIV RNA level in early infection is predicted by viral load in the transmission source
- 24 April 2010
- journal article
- basic science
- Published by Wolters Kluwer Health in AIDS
- Vol. 24 (7) , 941-945
Abstract
Objective: HIV-1 viral load in early infection predicts the risk of subsequent disease progression but the factors responsible for the differences between individuals in viral load during this period have not been fully identified. We sought to determine the relationship between HIV-1 RNA levels in the source partner and recently infected recipient partners within transmission pairs. Methods: We recruited donor partners of persons who presented with acute or recent (r = 0.55, P = 0.006). Conclusion: The strong correlation between HIV-1 RNA levels within HIV transmission pairs indicates that virus characteristics are an important determinant of viral load in early HIV infection.Keywords
This publication has 15 references indexed in Scilit:
- Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsJournal of Experimental Medicine, 2008
- Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival AdvantagePLOS Pathogens, 2008
- The Relation Between Symptoms, Viral Load, and Viral Load Set Point in Primary HIV InfectionJAIDS Journal of Acquired Immune Deficiency Syndromes, 2007
- Higher Set Point Plasma Viral Load and More-Severe Acute HIV Type 1 (HIV-1) Illness Predict Mortality among High-Risk HIV-1-Infected African WomenClinical Infectious Diseases, 2006
- Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1Journal of Virology, 2006
- Reversion of CTL escape–variant immunodeficiency viruses in vivoNature Medicine, 2004
- HLA Allele Sharing and HIV Type 1 Viremia in Seroconverting Zambians with Known Transmitting PartnersAIDS Research and Human Retroviruses, 2004
- Relationship between In Vitro Human Immunodeficiency Virus Type 1 Replication Rate and Virus Load in PlasmaJournal of Virology, 2003
- Virus Load during Primary Human Immunodeficiency Virus (HIV) Type 1 Infection Is Related to the Severity of Acute HIV Illness in Kenyan WomenClinical Infectious Diseases, 2002
- Association of HLA profiles with early plasma viral load, CD4+ cell count and rate of progression to AIDS following acute HIV-1 infectionAIDS, 1998