Integrin Signaling as a Cancer Drug Target
Open Access
- 24 July 2013
- journal article
- review article
- Published by Wiley in ISRN Cell Biology
- Vol. 2013, 1-14
Abstract
Integrins are transmembrane receptors that mediate cell adhesion to neighboring cells and to the extracellular matrix. Here, the various modes in which integrin-mediated adhesion regulates intracellular signaling pathways impinging on cell survival, proliferation, and differentiation are considered. Subsequently, evidence that integrins also control crucial signaling cascades in cancer cells is discussed. Lastly, the important role of integrin signaling in tumor cells as well as in stromal cells that support cancer growth, metastasis, and therapy resistance indicates that integrin signaling may be an attractive target for (combined) cancer therapy strategies. Current approaches to target integrins in this context are reviewed.Keywords
This publication has 155 references indexed in Scilit:
- Integrin αv Expression Is Required for the Acquisition of a Metastatic Stem/Progenitor Cell Phenotype in Human Prostate CancerThe American Journal of Pathology, 2011
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin SignalingCell, 2009
- Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue StiffeningCurrent Biology, 2009
- Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 DegradationMolecular Cell, 2008
- Structural Basis for the Autoinhibition of Focal Adhesion KinaseCell, 2007
- Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor inductionCancer Cell, 2004
- IntegrinsCell, 2002
- Anoikis mechanismsCurrent Opinion in Cell Biology, 2001
- The Hallmarks of CancerCell, 2000
- Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv IntegrinsCell, 1998