Normalization of Muc5b ameliorates airway mucus plugging during persistent Pseudomonas aeruginosa infection in the CFTR–/– rat

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Abstract
Although highly effective modulator therapies for cystic fibrosis (CF) have improved mucus-related outcomes of disease for people with CF, eradication of Pseudomonas aeruginosa (PA) infection has not been achieved in this population. In addition, current therapies for CF do not target mucin hypersecretion directly. Here, we show that a novel approach of normalizing airway Muc5b hypersecretion ameliorates infection-induced mucus plugging and neutrophilic inflammation during persistent PA infection in CFTR–/– rats.
Funding Information
  • HHS | NIH | National Heart, Lung, and Blood Institute (1K08HL131867)
  • HHS | NIH | National Heart, Lung, and Blood Institute (1R01HL153079)
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (5P30DK072482)
  • Cystic Fibrosis Foundation (ROWE19R0)
  • Cystic Fibrosis Foundation (BIRKET20A0)
  • Cystic Fibrosis Foundation (BIRKET20G0)
  • Cystic Fibrosis Foundation (BIRKET20A0-KBoost)

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