Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy
- 14 April 2016
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 127 (15) , 1912-1922
Abstract
Key Points: Early postnatal loss of Pten protein in mice with Nf1 haploinsufficiency causes a fatal juvenile myeloproliferative neoplasm. Akt and MAPK activities are elevated in juvenile mice with Nf1 haploinsufficiency and Pten protein loss.Keywords
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