Serial Multiple-Site Biopsies in Patients with Bladder Cancer

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Abstract
A prospective study was done on 52 patients with bladder cancer to determine the incidence of atypia, carcinoma in situ and carcinoma in selected site biopsies from normal-appearing mucosa at the time of initial and subsequent endoscopy. Biopsies at initial endoscopy revealed abnormalities in 33% of the patients, while 77% of 43 patients undergoing 3-mo. selected site biopsies had at least 1 abnormal biopsy during a 1-yr period.