Magnetic Nanoparticles for Therapy and Diagnostics

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Abstract
The research and utilization of the magnetic nanoparticles in, e.g., biology and medicine have been preferentially oriented on magnetite Fe 3 O 4 and maghemite γ-Fe 2 O 3 . The complex oxides allow a better control of the magnetic properties in a desirable way. We demonstrate this approach on an example of the La 1-x Sr x MnO 3 perovskites from the point of view of their use in self-controlled magnetic fluid hyperthermia and increase of contrast in magnetic resonance imaging. With materials possessing suitable values of transition temperature T C , coercivity and magnetization, the heating power generated by the nanoparticles was estimated by two independent methods and they were finally employed in vitro and in vivo hyperthermia experiments.