Dihydromonacolin L and monacolin X. new metabolites those inhibit cholesterol biosynthesis.

Authors:
  • AEAkira Endo
    Akira Endo
  • KHKeiji Hasumi
    Keiji Hasumi
  • TNTsuneo Nakamura
    Tsuneo Nakamura
  • MKMamoru Kunishima
    Mamoru Kunishima
  • MMMinoru Masuda
    Minoru Masuda
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Abstract
Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.