Synthesis of Tetracyclic-Fused Dihydroindeno[2,1-b]chromenes via Palladium-Catalyzed Alkyne Insertion and C–H Bond Activation

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Abstract
An unprecedented Pd-catalyzed cascade alkyne insertion/Heck/C-H activation reaction of o-iodophenyl alkenyl ethers and diarylacetylenes has been developed. Diversified tetracyclic-fused dihydroindeno[2,1-b]chromenes bearing a quaternary center were constructed in an efficient, straightforward, and atom-economic way with good to excellent yields. The protocol features high bonding efficiency, operational simplicity, broad substrate scope, and easy scale-up.
Funding Information
  • Natural Science Research of Jiangsu Higher Education Institutions of China (22KJB150022)
  • National Key Research and Development Program of China (2021YFE0107000)
  • National Natural Science Foundation of China (52074339)
  • Jiangsu Key Laboratory of Function Control Technology for Advanced Materials, Jiangsu Ocean University (jsklfctam202302)

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