Catalytic Asymmetric Synthesis of Mixed 3,3′‐Bisindoles and Their Evaluation as Wnt Signaling Inhibitors
- 25 January 2013
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 52 (9) , 2486-2490
Abstract
TOP class: The first efficient catalytic asymmetric coupling reaction of indoles with isatin-derived nitroalkenes was accomplished by using a complex consisting of a chiral imidazoline aminophenol ligand (1; see scheme) and Cu(OTf)2. Biological activity of the newly formed chiral 3,3′-bisindoles was also confirmed in a Wnt signaling inhibitory assay.Keywords
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