Outcome of Pregnancies Complicated by Sickle Cell and Sickle-C Hemoglobinopathies

Authors:
  • MSMuhieddine A.-F. Seoud
    Muhieddine A.-F. Seoud
  • CCCatherine Cantwell
    Catherine Cantwell
  • GNGeorgia Nobles
    Georgia Nobles
  • DLDonald L. Levy
    Donald L. Levy
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Abstract
Retrospective analysis was made of office and hospital records of patients with sickle cell hemoglobinopathies. Blood products were transfused only when indicated for symptomatic anemia, severe anemia with a hematocrit less than 18%, sickle crisis, cardiovascular instability, and preoperatively. The Fisher exact test and the Student t test were used for statistical analysis: PPP<0.05), respectively. There were two intrauterine fetal deaths and one neonatal death in the SSD group and one neonatal death in the SCD group. The perinatal mortality was 10.5% and 2.9%, respectively. Despite advances in perinatal medicine and hematology, conservative management of sickle cell disease in pregnancy is still associated with significant maternal and perinatal morbidity and mortality.