LONG-TERM RENAL FUNCTION IN KIDNEY DONORS

Authors:
  • FVFlavio Vincenti
    Flavio Vincenti
  • WAWilliam J. C. Amend
    William J. C. Amend
  • GKGeorge Kaysen
    George Kaysen
  • NFNicholas Feduska
    Nicholas Feduska
  • JBJytte Birnbaum
    Jytte Birnbaum
  • RDRob Duca
    Rob Duca
  • OSOscar Salvatierra
    Oscar Salvatierra
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Abstract
Twenty patients who underwent uninephrectomy for kidney donation between 1964 and 1968 participated in a long-term study of the function of the solitary kidney. Mean follow up after uninephrectomy was 15.8 +/- .3 years. One patient with a strong family history of essential hypertension developed de novo mild hypertension. The current creatinine clearance of the donors was 80 +/- 4 ml/min. The 1-week, 3-6 months and 14-18 years postuninephrectomy percentages of predonation creatinine clearance were 72 +/- 3%, 76 +/- 3% and 78 +/- 2%, respectively. The 24-hr urine protein excretion in kidney donors was significantly higher than in controls (141 +/- 20 mg vs. 74 +/- 3 mg, respectively, P less than .0005). Except for one donor who may have developed glomerulonephritis, the donors had normal urinary albumin excretion. The cause of the slightly elevated nonalbumin proteinuria is not known. However, this long-term study of kidney donors shows no adverse effects on the blood pressure and renal function after many years of compensatory hyperfiltration.

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