Pulmonary Alveolar Proteinosis in Workers at an Indium Processing Facility
- 1 March 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Respiratory and Critical Care Medicine
- Vol. 181 (5) , 458-464
Abstract
Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage–colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism.Keywords
This publication has 33 references indexed in Scilit:
- How can a chemical element elicit complex immunopathology? Lessons from mercury-induced autoimmunityTrends in Immunology, 2009
- Characteristics of a Large Cohort of Patients with Autoimmune Pulmonary Alveolar Proteinosis in JapanAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Pathogenic Role of Environmental Toxins in Immune-Mediated Liver DiseasesJournal of Immunotoxicology, 2008
- Pulmonary alveolar proteinosisChronic Respiratory Disease, 2006
- Pulmonary Alveolar Proteinosis and End-Stage Pulmonary FibrosisJournal of Thoracic Imaging, 2005
- Pulmonary alveolar proteinosis mimicking idiopathic pulmonary fibrosisAnnals of Diagnostic Pathology, 2003
- Coexisting Endogenous Lipoid Pneumonia, Cholesterol Granulomas, And Pulmonary Alveolar Proteinosis in a pediatric Population: A Clinical, Radiographic, and Pathologic CorrelationPediatric Pathology, 1992
- Pulmonary Alveolar Proteinosis and Cement Dust: A Case ReportJournal of Occupational and Environmental Medicine, 1989
- Ammonia Inhalation1985
- Acute silicoproteinosis.Thorax, 1977