Unexpected Adrenergic Effect of Chlorpromazine: Eating Elicited by Injection into Rat Hypothalamus
Authors:
- 8 August 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3893) , 609-611
Abstract
Although chlorpromazine is believed to block adrenergic transmission, injection of this drug into the hypothalamus of satiated rats does not block norepinephrine-elicited eating, but instead mimics norepinephrine by eliciting eating. The amount of eating elicited by norepinephrine and by chlorpromazine is reliably correlated. These results suggest that endogenous norepinephrine mediates eating elicited by centrally injected chlorpromazine.Keywords
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