Two Mutations of synaptic transmission in Drosophila
Authors:
- Y. N. JanYJY. N. Jan
- 19 May 1977
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 198 (1130) , 87-108
Abstract
Evoked transmitter release is abnormal at the larval neuromuscular junctions of two Drosophila mutants. Following a single nerve impulse, the increased calcium conductance at the nerve terminal, which lasts for 1 ms in normal larvae, lasts for at least 60 ms in one mutant and several seconds in the other. Both mutations appear to affect the same gene on the X-chromosome. Normal larvae treated with 4-aminopyridine, a potassium channel blocking agent, mimic the abnormal synaptic transmission of one mutant. Normal larvae treated with tetraethylammonium, another potassium channel blocking agent, mimic the abnormal synaptic transmission of the other mutant. From these and other experiments, we suggest that the abnormal neuromuscular transmission in these mutants may be caused by defective potassium channels in the nerve terminal membrane.Keywords
This publication has 17 references indexed in Scilit:
- Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.Proceedings of the National Academy of Sciences, 1976
- Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogasterNature, 1976
- Synaptic transmission in squid giant synapse after potassium conductance blockage with external 3- and 4-aminopyridineBiophysical Journal, 1976
- Interactions of aminopyridines with potassium channels of squid axon membranesBiophysical Journal, 1976
- Temperature-Sensitive Mutations in Drosophila melanogaster , VII. A Mutation (
para
ts
) Causing Reversible Adult ParalysisProceedings of the National Academy of Sciences, 1971
- Patterned Neural Activity of a Mutant Drosophila melanogasterProceedings of the National Academy of Sciences, 1970
- Co‐operative action of calcium ions in transmitter release at the neuromuscular junctionThe Journal of Physiology, 1967
- BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTIONProceedings of the National Academy of Sciences, 1967
- Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium ChlorideJournal of General Physiology, 1965
- Propagation of electric activity in motor nerve terminalsProceedings of the Royal Society of London. B. Biological Sciences, 1965