Water diffusion reveals networks that modulate multiregional morphological plasticity after repetitive brain stimulation
- 11 March 2014
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 111 (12) , 4608-4613
Abstract
Significance: Repetitive brain stimulation is an established experimental protocol that induces plasticity in the stimulated site. Recent evidence indicates additional plasticity-related changes in remote nonstimulated regions. However, the neural substrates underlying the remote effects are unknown. Diffusion-weighted MRI (DWI) probes water diffusion and can be used to estimate morphological changes in cortical tissue that occur with the induction of plasticity. We used DWI to evaluate morphological changes induced by repetitive brain stimulation in human brains. Our results reveal that synchronized fluctuations in the morphology of microstructures between stimulated and remote regions might form identify networks that allow retention of plasticity-related morphological changes in remote regions. These results increase our understanding of the effects of stimulation-induced plasticity on multiple brain regions.Keywords
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