NMDAR autoimmune encephalitis associated with Sjögren’s syndrome

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Abstract
N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare autoimmune encephalitis characterised by high morbidity and mortality, often necessitating intensive care. We report the case of a woman in her early 20s who presented with fever, altered sensorium, dyskinesia, keratoconjunctivitis sicca and xerostomia. A diagnosis of NMDA receptor encephalitis combined with Sjögren’s syndrome (SS) was established based on her history, clinical findings, biochemical analysis and radiological imaging. The condition was successfully managed with immunotherapy and other supportive treatments. This rare combination of NMDA receptor encephalitis and SS presents overlapping central nervous system manifestations, posing a diagnostic challenge.

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