The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling

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Abstract
The role of NRG1/ERBB signaling in endothelial cells is not completely understood. Our study contributes to the understanding of spatiotemporal heterogeneity of myocardial autocrine and paracrine responses following cardiac injury and shows a role of endothelial autocrine NRG1/ERBB4 signaling in the modulation of hypertrophic and fibrotic responses during early cardiac remodeling.
Funding Information
  • DocPro Ph.D. fellowship (PID33081)
  • Dehousse Ph.D. fellowship
  • IOF/SBO research grant (PID34923)
  • GOA grant (PID36444)
  • Senior Clinical Investigator fellowship
  • Scientific Research Flanders (1842219N, G02019N, G021420N)
  • ERA.NET RUS PLUS (Project Consortium 278)

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