Virus-associated Hemophagocytic Syndrome Following Bone Marrow Transplantation

Authors:
  • RRRudolph Roskos
    Rudolph Roskos
  • CHCurtis A. Hanson
    Curtis A. Hanson
  • VCValerie Castle
    Valerie Castle
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Abstract
Multiple-organ infiltration by mature, benign erythrophagocytic histiocytes is the pathologic hallmark of the virus-associated hemophagocytic syndrome (VAHS). Although VAHS has been described in a number of clinical settings, it has been reported following bone marrow transplantation (BMT) only once previously. Our report identifies the clinical and laboratory features associated with VAHS and compares the immune defects described in VAHS with those known to occur following BMT.