Biliary Excretion of Quaternary Ammonium Compounds and Tertiary Amines in the Rat
Authors:
- 1 September 1971
- journal article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 30 (1-2) , 59-68
Abstract
The biliary excretion of some isotopically labelled quaternary ammonium compounds and tertiary amines have been studied in rats after intravenous administration. The elimination of radioactivity into the bile was followed 4–6 hours. The amount of radioactivity eliminated ranged from 0.0–54% of the given doses of activity. Chromatographic studies indicated that only a small fraction of the activity eliminated into the bile was attributable to the original compound in most of the cases in which extensive excretion of radioactivity was noted. Metabolites were formed which seemed to be more polar than the original compounds. Molecular properties for biliary excretion are discussed.Keywords
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