Human Nuclear NAD + ADP-Ribosyltransferase(polymerizing): Organization of the Gene
Authors:
- Ulrich NaglUNUlrich Nagl
- Herbert HerzogHHHerbert Herzog
- Rainer SchneiderRSRainer Schneider
- Manfred SchweigerMSManfred Schweiger
- 1 October 1989
- journal article
- research article
- Published by SAGE Publications in DNA
- Vol. 8 (8) , 575-580
Abstract
Human nuclear NAD+: protein ADP-ribosyltransferase(polymerizing) [pADPRT; poly(ADP-ribose)polymerase; EC 2.4.2.30] is a DNA-dependent protein-modifying enzyme composed of several domains important for DNA binding, automodification, and NAD binding. We report that the human pADPRT gene is 43 kb in length and is split into 23 exons. All the intron–exon boundaries correspond to a canonical splice consensus sequence. Each of the four metal coordinating sites putatively forming the two zinc fingers of the DNA-binding domain is encoded separately. The automodification domain and the NAD-binding domain are coded for by 4 and 12 exons, respectively.Keywords
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