Effect of distamycin a on the structure and template activity of DNA in RNA — polymerase system
Authors:
- Ch. ZimmerCZCh. Zimmer
- H. ThrumHTH. Thrum
- 16 March 1970
- journal article
- Published by Wiley in FEBS Letters
- Vol. 7 (1) , 90-94
Abstract
It is shown that native and denatured DNA form complexes with the oligopeptide‐antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA‐polymerase system is due to the interference of the antibiotic with DNA.Keywords
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