Identification of defensin binding to C1 complement
Authors:
- Oded SzoldOSOded Szold
- Pak H. PoonPPPak H. Poon
- Yiou TsengYTYiou Tseng
- Tomas GanzTGTomas Ganz
- 19 December 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 356 (2-3) , 169-173
Abstract
In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin. Binding of defensins to C complement represents a newly recognized bridge between the complement‐ and phagocyte‐mediated host defenses, and a potential mechanism for protecting infected tissue from cytotoxic injury by defensin.Keywords
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