Figure 2 from Mechanisms Underlying Cedazuridine-Mediated Enhancement of Oral Decitabine Bioavailability

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Abstract
Cedazuridine restores oral decitabine bioavailability to intravenous-equivalent levels. A, Plasma concentration–time profiles of decitabine following intravenous or oral (10 mg/kg) administration in WT mice, with or without oral co-administration of oral cedazuridine (3 mg/kg). Cedazuridine markedly increased oral decitabine exposure, restoring systemic exposure to levels comparable with intravenous dosing. B, Plasma concentration–time profiles of decitabine following oral administration (10 mg/kg) in WT vs. CDA-KO mice, with or without oral cedazuridine (3 mg/kg). Cedazuridine co-administration in WT mice mimicked the effect of CDA deletion, producing similar plasma exposures. Data are presented as mean ± SEM (n = 5 mice per group).