Effect of Cyclic AMP on Histamine Release Induced by Compound 48/80

Authors:
  • MEMadeleine Ennis
    Madeleine Ennis
  • FPFrederick L. Pearce
    Frederick L. Pearce
Publisher website
Google Scholar
Abstract
Bu2 cAMP(N6, O2′-dibutyryl adenosine-3′,5′-cyclic monophosphate) inhibited the response of rat peritoneal mast cells to compound 48/80 in the presence of calcium ions. In the absence of calcium, the nucleotide partially prevented the desensitization induced by chelating agents. The response of cells, allowed to accumulate Bu2 cAMP in the presence of calcium (to avoid depletion of intracellular stores of the ion) and then challenged in the absence of extracellular calcium, was also inhibited. These results are discussed in terms of the postulated effects of Bu2 cAMP on the calcium-gating mechanism operative in histamine secretion.