Synthesis and in vitro Antineoplastic Evaluation of Certain 16‐(4‐Substituted Benzylidene) Derivatives of Androst‐5‐ene
Authors:
- 21 October 2004
- journal article
- research article
- Published by Wiley in Chemistry & Biodiversity
- Vol. 1 (10) , 1529-1536
Abstract
In a systematic effort aimed at identifying new steroidal cytotoxic agents with potent antiproliferative activity against cancer cells, we synthesized certain 16‐[4‐(NO2, CN, and i‐Pr)substituted]benzylidene derivatives of androst‐5‐ene, 7–25, with pyrrolidino functionality in the 3β‐position of the steroid nucleus, i.e., 13–18 and 25. The selected compounds were examined for their cytotoxicity against a panel of three human cancer cell lines at the National Cancer Institute (NCI), Bethesda, USA. The results presented herein provide experimental evidence that compounds 7, 9, 10, 12, 16, and 19–21 induced apoptosis in human cancer cells.Keywords
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