The E. coli β-lactamase attenuator mediates growth rate-dependent regulation

Authors:
  • BEBengt
    Bengt
  • [A[Aring]
    [Aring]
  • KJKe Jaurin
    Ke Jaurin
  • TGThomas Grundström
    Thomas Grundström
  • TEThomas Edlund
    Thomas Edlund
  • SNStaffan Normark
    Staffan Normark

Abstract
We have identified a new control or attenuator region in the chromosomal beta-lactamase operon of Escherichia coli. A single base alteration within its attenuator led to a loss in the cell's ability to coordinate its content of beta-lactamase with growth rate. We suggest a mechanism through which this mode of regulation operates.

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