Automated glycan assembly using the Glyconeer 2.1 synthesizer
- 10 April 2017
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 114 (17) , E3385-E3389
Abstract
Significance: Rapid access to defined, pure biomacromolecules is key to biochemical and biophysical investigations as evidenced by the impact automated solid-phase synthesis of oligonucleotides and oligopeptides had on basic research. Here, a strategy as well as a new instrument to routinely access oligosaccharides by automated synthesis is reported. The method produces glycans quickly and reliably to accelerate fundamental advances in glycobiology.Keywords
Funding Information
- EC | European Research Council (ERC-2008-AdG)
This publication has 21 references indexed in Scilit:
- The Logic of Automated Glycan AssemblyAccounts of Chemical Research, 2015
- Automated solid-phase peptide synthesis to obtain therapeutic peptidesBeilstein Journal of Organic Chemistry, 2014
- Toward Automated Oligosaccharide SynthesisAngewandte Chemie International Edition, 2011
- Oligosaccharide assembly by one-pot multi-step strategyOrganic & Biomolecular Chemistry, 2007
- Mass Spectrometry and Protein AnalysisScience, 2006
- Automated Solid-Phase Synthesis of OligosaccharidesScience, 2001
- The Sequence of the Human GenomeScience, 2001
- An automated multiplex oligonucleotide synthesizer: development of high-throughput, low-cost DNA synthesis.Proceedings of the National Academy of Sciences, 1995
- Synthesis of deoxyoligonucleotides on a polymer supportJournal of the American Chemical Society, 1981
- Solid Phase Peptide Synthesis. I. The Synthesis of a TetrapeptideJournal of the American Chemical Society, 1963