Aminocatalytic Alkylation of Indene‐2‐Carbaldehydes via Pentaenamine Activation
Authors:
- 10 January 2022
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 364 (5) , 974-979
Abstract
In the manuscript an application of amino isobenzofulvene intermediates as pentaenamines undergoing 1,6‐addition is described. As a result an alkylation of the indene ring of the starting indene‐2‐carbaldehydes with para‐quinone methides is achieved. Stereoselectivity of the process is controlled by C2‐symmetric 2,5‐diphenylpyrrolidine. The developed process exploits the reactivity of amino isobenzofulvene intermediates derived from indene‐2‐carbaldehydes in a non‐cycloadditive manner. magnified imageKeywords
Funding Information
- Wydział Chemiczny, Politechnika Łódzka
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