One-pot synthesis of 2,5-diketopiperazine with high titer and versatility using adenylation enzyme
Authors:
- 10 June 2022
- journal article
- research article
- Published by Springer Nature in Applied Microbiology and Biotechnology
- Vol. 106 (12) , 4469-4479
Abstract
2,5-Diketopiperazine (DKP) is a cyclic peptide composed of two amino acids and has been recently reported to exhibit various biological activities. DKPs haKeywords
Funding Information
- Japan Society for the Promotion of Science (21H01734)
- Nissin Sugar
This publication has 33 references indexed in Scilit:
- 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural ProductsChemical Reviews, 2012
- One-Pot Synthesis of Diverse dl -Configuration Dipeptides by a Streptomyces d -Stereospecific AmidohydrolaseApplied and Environmental Microbiology, 2011
- Use of Diketopiperazines for Determining Absolute Configurations of α-Substituted Serines by 1H-NMR SpectroscopyHETEROCYCLES, 2009
- Microwave‐Assisted Stereoselective One‐Pot Synthesis of Symmetrical and Unsymmetrical 2,5‐Diketopiperazines from Unprotected Amino AcidsEuropean Journal of Organic Chemistry, 2008
- Impact of Epimerization Domains on the Intermodular Transfer of Enzyme‐Bound Intermediates in Nonribosomal Peptide SynthesisChemBioChem, 2006
- An investigation into the biological activity of the selected histidine-containing diketopiperazines cyclo(His-Phe) and cyclo(His-Tyr)Journal of Pharmacy and Pharmacology, 2004
- In Vivo Production of Artificial Nonribosomal Peptide Products in the Heterologous Host Escherichia coliApplied and Environmental Microbiology, 2004
- Penicillin acylase-catalyzed peptide synthesis in aqueous medium: a chemo-enzymatic route to stereoisomerically pure diketopiperazinesTetrahedron: Asymmetry, 2003
- dd-Diketopiperazines: Antibiotics Active against Vibrio anguillarum Isolated from Marine Bacteria Associated with Cultures of Pecten maximusJournal of Natural Products, 2003
- The effect of the isomers of cyclo(Trp-Pro) on heart and ion-channel activityJournal of Pharmacy and Pharmacology, 2002