Effect of Continuous Intravenous Infusion of Zidovudine (AZT) in Children with Symptomatic HIV Infection
Authors:
- Janie EddyJEJanie Eddy
- Judy FalloonJFJudy Falloon
- Frank M. BalisFrank M. Balis
- Robert F. MurphyRMRobert F. Murphy
- Howard MossHMHoward Moss
- Pam WoltersPWPam Wolters
- Pim BrouwersPBPim Brouwers
- Paul JarosinskiPJPaul Jarosinski
- Marc RubinMRMarc Rubin
- Samuel BroderSBSamuel Broder
- Robert YarchoanRYRobert Yarchoan
- 6 October 1988
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 319 (14) , 889-896
Abstract
To produce concentrations of zidovudine (AZT) in plasma and cerebrospinal fluid that would provide constant inhibition of the replication of human immunodeficiency virus (HIV), we gave AZT by continuous intravenous infusion to 21 children ranging in age from 14 months to 12 years who had acquired HIV infection through transfusions or perinatally. All patients were symptomatic before AZT treatment (Class P2 of the Centers for Disease Control); 13 (62 percent) had evidence of neurodevelopmental abnormalities. The mean CD4/CD8 ratio was 0.18; 11 patients had CD4 counts below 0.2X109 per liter.Keywords
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