Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria
Authors:
Open Access
- 1 January 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (1) , 385-387
Abstract
Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli . These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.Keywords
This publication has 14 references indexed in Scilit:
- Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNAAntimicrobial Agents and Chemotherapy, 2005
- Development and Validation of a Diagnostic DNA Microarray To Detect Quinolone-Resistant Escherichia coli among Clinical IsolatesJournal of Clinical Microbiology, 2004
- Quinolone-Resistant Haemophilus influenzae in a Long-Term-Care Facility: Nucleotide Sequence Characterization of Alterations in the Genes Encoding DNA Gyrase and DNA Topoisomerase IVAntimicrobial Agents and Chemotherapy, 2004
- Novel AntibacterialClassAntimicrobial Agents and Chemotherapy, 2003
- Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNAJournal of Molecular Biology, 2002
- Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3The EMBO Journal, 2001
- Topoisomerase IV is a target of quinolones in Escherichia coli.Proceedings of the National Academy of Sciences, 1995
- Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coliAntimicrobial Agents and Chemotherapy, 1990
- Energy coupling in DNA gyrase and the mechanism of action of novobiocinProceedings of the National Academy of Sciences, 1978
- Nalidixic acid resistance: A second genetic character involved in DNA gyrase activityProceedings of the National Academy of Sciences, 1977