Allopurinol augmentation for poorly responsive schizophrenia
Authors:
- D. R. LaraDLD. R. Lara
- M. G. BrunsteinMBM. G. Brunstein
- E. S. GhisolfiEGE. S. Ghisolfi
- M. I. LobatoMLM. I. Lobato
- P. Belmonte-De-AbreuPBP. Belmonte-De-Abreu
- D. O. SouzaDSD. O. Souza
- 1 July 2001
- journal article
- case report
- Published by Wolters Kluwer Health in International Clinical Psychopharmacology
- Vol. 16 (4) , 235-237
Abstract
Adenosine has been proposed to contribute to the pathophysiology of schizoprenia and as a target for therapeutic intervention. In the lack of direct adenosine agonists, allopurinol may indirectly elevate adenosine levels by inhibiting degradation of purines. We report two cases of poorly responsive schizophrenic patients who improved considerably with add-on allopurinol 300 mg/day. Their clear clinical improvement warrant further investigation of allopurinol, as well as other purinergic strategies, for the treatment of schizophrenia.Keywords
This publication has 21 references indexed in Scilit:
- Placebo-Controlled Trial of Glycine Added to Clozapine in SchizophreniaAmerican Journal of Psychiatry, 2000
- Dipyridamole in the treatment of schizophrenia: adenosine-dopamine receptor interactionsJournal of Clinical Pharmacy and Therapeutics, 2000
- Attenuation of the Neuropsychiatric Effects of Ketamine With LamotrigineArchives of General Psychiatry, 2000
- Deprenyl Augmentation for Treating Negative Symptoms of Schizophrenia: A Double-Blind, Controlled StudyJournal of Clinical Psychopharmacology, 1999
- Clozapine Plus Lamotrigine in Treatment-Resistant SchizophreniaArchives of General Psychiatry, 1999
- Effects of Carbamazepine and Valproate on Haloperidol Plasma Levels and on Psychopathologic Outcome in Schizophrenic PatientsJournal of Clinical Psychopharmacology, 1999
- Efficacy of High-Dose Glycine in the Treatment of Enduring Negative Symptoms of SchizophreniaArchives of General Psychiatry, 1999
- Adenosine-dopamine interactions in the ventral striatumPsychopharmacology, 1997
- Seizures and SchizophreniaSchizophrenia Bulletin, 1997
- Stereoselective Antagonism of Phencyclidine's Discriminative Properties by Adenosine Receptor AgonistsScience, 1982