Effect of Somatostatin in Necrolytic Migratory Erythema of Glucagonoma

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Abstract
A 63‐year‐old woman with necrolytic migratory erythema associated with a glucagonoma in the pancreas is described. The diagnosis was suggested on the basis of a characteristic lesion in skin biopsy. Infusion of somatostatin (25 μg/h) for 48 hours was followed by a rapid and almost complete healing of the skin eruptions. Serum glucagon was depressed during infusion. No significant changes in plasma glucose were detected. As the patient experienced a cramp‐like sensation after cessation of somatostatin infusion, a tail‐off period in the infusion program is advocated. The pathogenesis of necrolytic erythema in glucagonoma is discussed.

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