Cleavage of Leishmania Mini-exon Sequence by Oligonucleotides Conjugated to a Dimidazole Construction
Authors:
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 16 (7-9) , 1721-1725
Abstract
RNA sequences derived from the Leishmania amazonensis mini-exon and pre-mini-exon sequences have been targeted with complementary oligonucleotides bearing a diimidazole construction mimicking active center of ribonuclease A. The conjugates were shown to cleave the target RNAs at specific positions.Keywords
This publication has 8 references indexed in Scilit:
- Antisense Oligonucleotides Containing an Internal, Non-Nucleotide-Based Linker Promote Site-Specific Cleavage of RNANucleic Acids Research, 1996
- Cleavage of tRNA with imidazole and spermine imidazole constructs: a new approach for probing RNA structureNucleic Acids Research, 1995
- Selective Hydrolysis of tRNA by Ethylenediamine Bound to a DNA Oligomer1The Journal of Biochemistry, 1994
- Antisense effect of oligodeoxynucleotides complementary to the mini-exon sequence of the protozoan parasite Leishmania amazonensisBiochimie, 1993
- Synthetic RNA-cleaving molecules mimicking ribonuclease A active center. Design and cleavage of tRNA transcriptsNucleic Acids Research, 1993
- Enhanced imidazole-catalyzed RNA cleavage induced by a bis-alkylguanidinium receptorJournal of the American Chemical Society, 1993
- Design of peptide-acridine mimics of ribonuclease activity.Proceedings of the National Academy of Sciences, 1992
- DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMESAnnual Review of Biochemistry, 1986