Simulated ischemia in live cerebral slices is mimicked by opening the Na+/K+ pump: clues to the generation of spreading depolarization

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Abstract
With stroke, traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug to aid brain recovery. Within 2 min of severe ischemia, a wave of spreading depolarization (SD) propagates through affected gray matter. More SDs arise over hours, expanding the injury. This period represents a therapeutic window to inhibit recurring SD and reduce neuronal damage, but we do not understand the underlying molecular sequence. Here, we argue for a novel molecule to target.
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Funding Information
  • Heart and Stroke Foundation of Canada (G-19-0024266)
  • Canadian Government | Natural Sciences and Engineering Research Council of Canada (RGPIN/04624-2017)
  • Canadian Government I New Frontiers in Research (NFRFE-2020-00978)

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