Sequence homology and structural comparison between the chromosomal human α1-antitrypsin and chicken ovalbumin genes
Authors:
- Margaret LeichtMLMargaret Leicht
- George L. LongGLGeorge L. Long
- T. ChandraTCT. Chandra
- Kotoku KurachiKKKotoku Kurachi
- Vincent J. KiddVKVincent J. Kidd
- Myles MaceMMMyles Mace
- Earl W. DavieEDEarl W. Davie
- Savio L. C. WooSWSavio L. C. Woo
- 1 June 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 297 (5868) , 655-659
Abstract
The human chromosomal alpha 1-antitrypsin gene has been cloned. This gene is approximately 5 kilobase pairs long and contains three intervening sequences in the peptide-coding region. DNA sequences coding for the amino and carboxyl termini of a alpha 1-antitrypsin have been identified. Human alpha 1-antitrypsin and chicken ovalbumin show significant sequences homology and belong to a common protein super-family. Yet the number, position and size of intervening sequences reveal that the two genes are dissimilar.Keywords
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