Improving Trastuzumab’s Stability Profile by Removing the Two Degradation Hotspots
- 1 June 2015
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 104 (6) , 1960-1970
Abstract
No abstract availableKeywords
Funding Information
- National Advanced Technology Research and Development Program of China (863) (2012AA02A302)
- The Municipal Commission of Science and Technology of Beijing (Z141100000514019)
This publication has 35 references indexed in Scilit:
- Asparagine Deamidation Dependence on Buffer Type, pH, and TemperatureJournal of Pharmaceutical Sciences, 2013
- Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated TemperaturesPLOS ONE, 2012
- Accurate Determination of Succinimide Degradation Products Using High Fidelity Trypsin Digestion Peptide Map AnalysisAnalytical Chemistry, 2011
- Charge variants in IgG1mAbs, 2010
- Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product DevelopmentPharmaceutical Research, 2010
- Recovery and purification process development for monoclonal antibody productionmAbs, 2010
- Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptidesElectrophoresis, 2010
- Isomerization in the CDR2 of a monoclonal antibody: Binding analysis and factors that influence the isomerization rateBiotechnology and Bioengineering, 2009
- Deamidation of Asparagine Residues: Direct Hydrolysis versus Succinimide-Mediated Deamidation MechanismsThe Journal of Physical Chemistry A, 2009
- Effects of protein aggregates: An immunologic perspectiveThe AAPS Journal, 2006