Evidence that latent collagenases are enzyme-inhibitor complexes

Authors:
  • ASA Sellers
    A Sellers
  • ECE Cartwright
    E Cartwright
  • GMG Murphy
    G Murphy
  • JRJ J Reynolds
    J J Reynolds
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Abstract
Specific collagenase from the culture media of various rabbit tissues and cells exists in active and latent forms. Latent collagenase is most effectively activated with 4-aminophenylmercuric acetate, a thiol-blocking reagent, strongly suggesting that latent forms are enzyme-inhibitor complexes. A collagenase inhibitor from bone cultures, which may be closely related to the inhibitor of such latent enzyme complexes, was partially characterized.

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