Phenol oxidative coupling of benzylisoquinoline alkaloids is catalysed by regio- and stereo-selective cytochrome P-450 linked plant enzymes: salutaridine and berbamunine

Authors:
  • MZMeinhart H. Zenk
    Meinhart H. Zenk
  • RGRoswitha Gerardy
    Roswitha Gerardy
  • RSRichard Stadler
    Richard Stadler
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Abstract
The alkaloids salutaridine and berbamunine are formed by intramolecular C–C and intermolecular C–O coupling, respectively, catalysed by cytochrome P-450 linked NADPH and O2 dependent microsomal bound plant specific enzymes.
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