ATP and ADP levels and epidermal replacement rate in the normal human skin and in some papulosquamous diseases of the skin

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Abstract
Adenosine tri-and diphosphate (ATP, ADP) were measured in the subcorneal and basal layers of epi dermis from patients with psoriasis, neurodermatitis and lichen planus and from healthy controls. In the controls the ATP comenl in the basal layers was 11.3 mmoles/ k.g dry weight and decreasetl 10 9.8 mmoles/kg in the subcorneal layers. The ADP content varicd bctwcen I and 2 mmoles/kg. The ATP levels in thc controls de creased 38 % af ter a 30-min period of anoxia with nitrogen as gas pbase. In non-involved skin in patients with the various disea$eS, the adenylate levels were similar to those of the controls. In the psoriatic lesion the ATP content was increased 33 % in subcorneal and 17 % in basat epi dermis. In neurodermalitis and Jichen planus there was no difference in the ATP content between affected and non-involvcd skin. The cffect o(anoxia on epidermal adenylates in psoriasis and neurodermatitis was similar lo that found in the controls but in lichen planus it was scarccly discernible. Using tetrachlorsalicylanilide as a marker, the epidermal replaccmcnt ratc was found to be increased about 2-fold in the non-involved and 7-fold in the involved psoriatic skin as compared with the control rate. In 2 patients with lichen planus the rate was about 4 times the comrol rate when measured in lesions but was not increased in non-involved skin. Neither this rate nor ihe relative epidermal height showed any correlation wilh ATP and ADP levels, irrespec1ive of tbe lesion studied.

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