Successful hematopoietic cell transplantation in a patient with X‐linked agammaglobulinemia and acute myeloid leukemia
Authors:
- Rolla F. Abu‐ArjaRARolla F. Abu‐Arja
- Troy R. TorgersonTTTroy R. Torgerson
- Robert W. HostofferRHRobert W. Hostoffer
- 20 April 2015
- journal article
- case report
- Published by Wiley in Pediatric Blood & Cancer
- Vol. 62 (9) , 1674-1676
Abstract
X‐linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19+ B‐cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674–1676.Keywords
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