Synthesis of optically active trifluorinated compounds: asymmetric Michael addition with hydrolytic enzymes

Authors:
  • TKTomoya Kitazume
    Tomoya Kitazume
  • TITakanobu Ikeya
    Takanobu Ikeya
  • KMKouichi Murata
    Kouichi Murata
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Abstract
Syntheses of optically active compounds possessing a trifluoromethyl group, via enzymatic chiral Michael addition reaction of 2-(trifluoromethyl)propenoic acid and synthesis of trifluoromethylated heterocycles, have been under-taken.